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S-phase arrest in response to glutamine deprivation in KRas-driven cancer cells can be reversed by aspartate....

S-phase arrest in response to glutamine deprivation in KRas-driven cancer cells can be reversed by aspartate.

A)  True    

B)  False

Science   Biology   
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Answer #1

Ans - The given statement is true.

S phase arrest in response to glutamine deprivation in kRas driven cancer cells is due to lack of deoxynucleotides needed for DNA synthesis . The lack of deoxynucleotides causes replicative stress leading to activation of the ataxia telangiectasia and Rad3- related protein (ATR)- mediated DNA damage pathway , which arrests cells in S- phase.

Aspartate which is a critical metabolite for deoxynucleotides biosynthesis and is generated by the transaminase reaction between glutamate and oxaloacetate , rescued the S-phase arrest caused by inhibition of glutamine utilisation .

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