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22) which of the following activity most likely leads to activation of protein kinase A? a....

22) which of the following activity most likely leads to activation of protein kinase A?
a. Activation of PI3 kinase and down stream Rac GTPase.
b. Activation of PLC by Gbeta gamma subunits.
c. Activation of adenylyl Cyclase by ga subunit.
d. Cytosolic Ca++ changes

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Answer #1

Correct option is C). Protein kinase A is very important for regulating activity of a protein and it does so by phosphorylating a protein. So this PKA is activated by Cyclic AMP. But another question which arose is how Cyclic AMP is activated?. The answer is, it is synthesised or activated from ATP by a plasma membrane enzyme called adenylyl cyclase and this cyclase is activated by G proteins. So in these series of steps i.e G Protein -> adenylyl cyclase -> Cyclic AMP -> PKA is activated.

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