Question

1. Define allosteric regulation. Does this type of regulation result in activation, inhibition, or both? Give an example of allosteric regulation.

Answer 1

allosteric regulation , regulate an enzyme by binding an effector molecule at a site different than the enzyme's active site.The site to which the effector binds is known as allosteric site or regulatory site. Allosteric sites allow effectors to attach to the protein, which results in conformational change involving protein dynamics.

Allosteric regulation results in both activation and inhibition.Effectors that help in rising the protein's function are referred to as allosteric activators, whereas those that decrease the protein's function are called allosteric inhibitors.

Example:-

Regulatory enzyme :-Phosphofructokinase

1) effector:- AMP

result:-Activation

Biochemical pathway:- Glycolysis

2) effector:-ATP

result:-Inhibition

Biochemical pathway:- Glycolysis

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