Question

The activity of β-adrenergic receptors is regulated by a. Phosphorylation by β-adrenergic receptor kinase (GRKs) b....

  1. The activity of β-adrenergic receptors is regulated by

a.

Phosphorylation by β-adrenergic receptor kinase (GRKs)

b.

Phosphorylation by Protein Kinase A (PKA)

c.

Agonist binding

d.

b and c

e.

a, b and c
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Answer #1

d. b and c

β-Adrenergic receptors are G-protein coupled transmembrane proteins.  Beta-adrenoceptors are coupled to Gs-proteins, which activate adenylyl cyclase to form cAMP from ATP. Increase in the cellular concentration of cAMP leads to enhanced cAMP-dependent protein kinase (PKA) activity which mediates the functional consequences of Gs-coupled receptor activation.  Agonist binding to βAR results in a conformational change leading to receptor coupling to Gsα subtype of hetero-trimeric G protein.

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