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Loss of VHL in renal cancer prevents the hydroxylation of HIFa and thusly stabilizes HIFa resulting...

Loss of VHL in renal cancer prevents the hydroxylation of HIFa and thusly stabilizes HIFa resulting in the induction of angiogenesis and the expression of glycolytic genes.

True or False

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Answer #1

Ans) This statement is true.

Von hippel lindau disease is caused when mutation occurs in VHL genes which are a tumour suppressing gene. And when mutation, loss or inactivation of this gene occurs it causes cancer and increased angiogenesis. And in case of renal cancer the HIFa is not hydroxylised making it stable; this causes subsequent rise in angiogenesis and also expression of glycotic genes starts.

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