Question

While it is widely believed that the GTPase Rheb directly activates mTORC1, the ability of PA (18:1-16:0) to activate mTORC1 in the absence of Rheb strongly suggests that it is the ability of Rheb to activate PLD that is the last step in the activation mTORC1. A) True B) False

Answer 1

True

mTOR, mammalian target of Rapamycin is involved in the signalling cascade for the regulation of cell growth and proliferation in response to hormones and amino acids.Phospholipase D and it's product phoshpatidic acid are the upstream regulators of mTOR signalling.Rag GTPase helps in translocation of mTOR from cytoplasm to lysosome.PLD 1 on stimulus from amino acids activates mTOR.Rheb activates PLD 1 in the absence of mitogenic stimulation.PLD 1 as the studies suggest is an effector of Rheb.