Question

Loss of heterozygosity enhances progression to carcinoma by increasing the rate of driver mutations in cancer cells.

True or False

Answer 1

And. True

A diploid organism is heterozygous at a gene locus when its cells contain two different alleles (one wild-type allele and one mutant allele) of a gene. The cell or organism is called a heterozygotespecifically for the allele in question, and therefore, heterozygosity refers to a specific genotype.

The loss of heterozygosity is a common occurrence in cancer, where it indicates the absence of a functional tumor suppressor gene in the lost region. However, many people remain healthy with such a loss, because there still is one functional gene left on the other chromosome of the chromosome pair.

So, loss of heterozygosity increase mutation becouse loss of tumour suppression gene in cells lead to increase in mutation rate In cancer cells.....

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