Question

S-phase arrest in response to glutamine deprivation in KRas-driven cancer cells can be reversed by aspartate.

A)  True    

B)  False

Answer 1

Ans) true

Explaination: this statement is true as S phase arrest in Kras driven cancer cells in response to gluatamine deprivation because glutamine required in G1 phase for synthesis of nucleotides which are required in S phase for replication so in absence or deprivation of glutamnie cell cycle of Kras driven cancer cell arrested at S phase but addition of aspartate reverse the SPhase arrest because glutamine metabolize to yield aspartate which is responsible for nucleotide synthesis so here by directly adding aspartate we can synthesize nucleotides and cell cycle do not arrest at S phase.