Question

EGF signals are enhanced by proton pumps that reduce the pH in endosomes carrying the endocytosed EGF receptor.

True or False

Answer 1

True: Many growing number of studies are showing that the pH of endosomal compartments controls proliferation, migration, stemness, and sensitivity to chemoradiation therapy in a variety of tumors. Endosomes are a crucial hub, mediating cellular communication with the external environment regulating the sorting and trafficking of vesicular cargo for degradation or recycling, endosomal pH determines the fate of extracellular signals including growth factor receptors and their ligands. Several critical regulators of endosomal pH have been identified, including multiple isoforms of the family of EGFs.