Question

Metabolic reprogramming in KRas-driven cancer cells involves glutaminolysis whereby glutamine is deamidated by glutaminase to glutamate, which is then deaminated by glutamate dehydrogenase to a-ketoglutarate and NH₄⁺.  a-ketoglutarate can then continue through the TCA cycle to citrate and exit the mitochondria where acetyl-CoA is regenerated for fatty acid synthesis.

1. True
2. False

Answer 1

A. True.

Explanation: KRas is Kirsten rat sarcoma viral oncogene homolog, it is one of the type of Ras gene and a frequently mutated oncogene in cancer. Glutamine is present in the abundant concentration in the cell. To meet the high demand for anabolism, the cancerous cells use the glutamine for the production of macromolecules such as nucleotide, amino acid, and lipid biosynthesis. This takes place as explained below.