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The loss of Smad4 coupled with the loss of PTEN is not common in human cancers...

The loss of Smad4 coupled with the loss of PTEN is not common in human cancers because both mutations lead to suppression of TGF-b signals. True or False

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these statement are false because Smad4 and PTEN Phosphatase both are tumor suppressor We know that loss of tumor suppressors causes cancer and in case of protooncogene gain of function causes cancer. In case of TGF-b signalling loss of Smad4 inhibit TGF-b signalling and causes (DPC) deleted pancreatic cancer (in case of human) . In other case PTEN phosphatase inhibit activation of PKB/AKT in Ras independent RTK pathway

PTEN PHOSPHATASE remove 3'phosphate of insitol 3,4 phosphate and inhibit cell cycle. Loss of PTEN PHOSPHATASE is causes cancer because it is a tumor suppressor gene.

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