The direct phosphorylation of glucose by inorganic phosphate is
a thermodynamically unfavorable reaction:
In the cell, glucose phosphorylation is accomplished by coupling the reaction to the hydrolysis of ATPATP, a highly exergonic reaction:
Typical concentrations of these intermediates in yeast cells are as follows:
[glucose-6-phospate] = 0.08mMmM
Assume a temperature of 25∘C∘C for all calculations.
What minimum concentration of glucose would have to be maintained in a yeast cell for the coupled reaction to be thermodynamically spontaneous?
Minimum concentration of Glucose is 7.712 nM
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