Question

How is it possible that the activation of PKA in various tissues leads to such different...

How is it possible that the activation of PKA in various tissues leads to such different responses in each tissue?

The different pace of cAMP degradation in each tissue

The presence of a different AKAP scaffold in each tissue

The presence of various PKA isoforms in each tissue

The presence of various G protein isoforms in each tissue

The presence of various GPCR isoforms in each tissue
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Answer #1

The presence of a different AKAP Scaffold in each tissue leads to different responses in each tissue.

PKA or protein kinase a has several functions in cells . AKAP or A Kinase Anchoring Proteins are Scaffold proteins. They are a group of proteins that binds to the regulatory subunit of the PKA and regulates its activity to a specific region of the cell. There are at least 50 different types of AKAPs are present. They leads to different responses of PKA in different tissues.

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