Imagine that you are comparing the DNA sequence of the collagen gene in different individuals. The collagen ORF does not contain introns. All individuals included in this study are normal, without any problem related to collagen. Your results show that some collagen ORF sequences are longer in some individuals. Which of the following would most likely represent the extra number of bases that you have observed?
Options:
(a)10, (b)11, (c)12, (d)13, (e)14, (f)15, (g)16
1. Answer: Options
C and F are correct
Explanation:
The genetic code is triplet i.e. each amino acid is specified by a
3-base sequence.
An insertion or deletion of bases not in multiples of three leads
to frame-shift mutations that alter the entire downstream
sequence.
It is given that different individuals exhibit different lengths of collagen gene. However, they all are normal. This can be due to the presence of 12 (12/3 = 4 amino acids) or 15 bases (15/3 = 5 amino acids).
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