Question

what sequencing method should you use to sequence a cancer patient's exome ?Explain why and give...

what sequencing method should you use to sequence a cancer patient's exome ?Explain why and give a summary of the approach.
Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Parallel sequencing, providing a faster turnaround time than Sanger sequencing or shotgunsequencing. Exome sequencingpanels can be expanded to include noncoding genes and other genetic elements that are relevant to cancer.

parallel sequencingexperiments can be used to detect chromosomal copy number variants (CNVs), translocations, and other structural variations .Methodsto detect somatic CNVs in cancerover come this issue by directly comparing read depths between a tumor and matched normal.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
If you had a genomic DNA sequence, but did not have any mRNA or cDNA sequencing...
If you had a genomic DNA sequence, but did not have any mRNA or cDNA sequencing data, how would you identify ORFs in a prokaryote genome? How would the method be different in eukaroytes?
Explain why evidence-based practice should take account of the patient's value and culture?
Explain why evidence-based practice should take account of the patient's value and culture?
You use the Sanger sequencing protocol to sequence the following DNA fragment: 5’-TGCACGGGTCAGCT-(primer site)-3’ Draw a...
You use the Sanger sequencing protocol to sequence the following DNA fragment: 5’-TGCACGGGTCAGCT-(primer site)-3’ Draw a picture of the resulting sequencing gel, with products ending in each of the four dideoxynucleotides (ddATP, ddTTP, ddCTP, and ddGTP) in separate lanes of the gel. Be sure to label each lane as ddATP, ddTTP, ddCTP, or ddGTP.
4. Give the most likely explanation for each of the following experiment observations prior to sequencing....
4. Give the most likely explanation for each of the following experiment observations prior to sequencing. a) Your proteins has an apparent molecular mass (Mr) of 50 KDa as determined by native SDS-PAGE. After treatment of protein with DTT or beta-mercaptoethanol, using the same technique now reveals 2 proteins of Mr 15 KDa and 35 KDa. Explain these observations. b) Size exclusion chromatography experiments indicate the native protein/enzyme has an apparent Mr of 200 KDa. Explain this observation. c) Describe...
When should you not use a correlation? Describe two situations where a correlation would not give...
When should you not use a correlation? Describe two situations where a correlation would not give a good numerical summary of the relationship between two quantitive variables. Illustrate each situation with a scatterplot and write a short paragraph explaining why the correlation would not be appropriate in each of these situations.
Why do many corporations continue to use the payback period method? Which method do you prefer?...
Why do many corporations continue to use the payback period method? Which method do you prefer? Explain why you prefer this method
What accounting method do you think most businesses use and why?
What accounting method do you think most businesses use and why?
What criteria should you use to determine whether recrystallization or sublimation will be a better method...
What criteria should you use to determine whether recrystallization or sublimation will be a better method of purification?
1. Explain new techniques that have improved cervical cancer screening. 2. As a biomedical scientist, you...
1. Explain new techniques that have improved cervical cancer screening. 2. As a biomedical scientist, you are provided with a smear from respiratory epithelium, the cells yielded nothing of diagnostic important for patient's management because the lesion was localized in the connective tissue. You are not the person that did the sampling. a. what then did the sample taker do wrong and how would you advise as sampling is concerned? please this is Histopathology question.
Which Method Will You Likely Use if You Take the Standard Deduction, and Why? IRS METHOD...
Which Method Will You Likely Use if You Take the Standard Deduction, and Why? IRS METHOD OR TAX COURT METHOD?
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT