Question

Describe how the product from glycolysis is converted to the activated metabolite acetyl-CoA. It is sufficient...

Describe how the product from glycolysis is converted to the activated metabolite acetyl-CoA. It is sufficient to state the total reaction. Where in the eukaryotic cells does this transformation take place?

What is meant by acetyl-CoA being an activated metabolite?

What are the enzyme complex that catalyzes conversion to acetyl-CoA, and how many enzymes and coenzymes does this complex consist of?

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Answer #1

The final product of glycolysis is Pyruvate,CH3COCOO

CH3COCOO- + CoA + NAD+CH3COSCoA + NADH + H+ + CO2

Pyruvate. Coenzyme~A AcetylCo~A

In eukaryotes this transformation occurs in mitochondria.

The acetyl group is linked to coenzyme A through thioester linkage which is highly reactive. Hydrolysis of this bond released 31 KJ of energy. Thus this linkage makes it highly reactive metabolite.

The enzyme which catalyzes this transformation is called Pyruvate Dehydrogenase complex.

This complex has three enzymes

1. Pyruvate dehydrogenase.

2. Dihydrolipoyl Transacetylase

3. Dihydrolipoyl Dehydrogenase.

This enzyme complex need coenzymes NAD, thiamine pyrophosphate, pantothenic acid.

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