Question

The myc gene has several ARE's in its 3' UTR. How would the deletion of these ARE's affect expression of the myc gene.

a-It would promote transcription of the myc gene.

b-It would result in methylation of the myc gene.

c-It would increase the production of the myc protein.

d-It would trigger the production of negative miRNA molecules

Answer 1

In this case, we need to remember two basic facts:

1) Myc gene is a protooncogene which means that it will promote cell proliferation. Specifically, it will promote the transcription of other genes in order to enhance the cell proliferation

2) On the other hand, the Adenylate-uridylate-rich elements (AREs) are elements that promote the degradation of mRNA in order to regulate the expression of a determined gene

If the AREs are depleted in the myc gene, it will induce the excessive translation of the myc protein, inducing excessive transcription. In some cases, this can lead to cancer.

So, the correct answer is c-It would increase the production of the myc protein.