Question

The cytosine nucleotide base of the dCpG dinucleotide DNA sequence in the human tumor suppressor gene,...

The cytosine nucleotide base of the dCpG dinucleotide DNA sequence in the human tumor suppressor gene, TP53, has been changed to dTpG by a mutation. Which of the following type of mutations is referred to this base change?

(d=deoxy;p=phosphodiester bond; C=cytosine; G=Guanine;T=Thymine)

Tranversion

Deletion

Transition

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Answer #1

Answer-Transition

Transition, in genetics and molecular biology, refers to a point mutation that changes a purine nucleotide to another purine (A ↔ G), or a pyrimidine nucleotide to another pyrimidine (C ↔ T).

Since Cytsoine and Thymine,Both are Pyrimidine this is a Transition

Transversion, in molecular biology, refers to a point mutation in deoxyribonucleic acid (DNA), where a single (two ring) purine is changed for a (one ring) pyrimidine, or vice versa.

In genetics, a deletion is a mutation in which a part of a chromosome or a sequence of DNA is left out during DNA replication .

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