Question

how can liposome be used to deliver choloroquine (a weak base) to alkalize the endosome (acidic)? just explain how liposome can help the drug choloroquine get to the endosome

Answer 1

Answer) Liposomes are generally vesicles or spherical lipid molecules, this is basically used as a carrier. Chloroquine is a drug used to treat malaria and also helps in cancer treatment. There is a mechanistic approach (proposed):(a) The weak base nature of chloroquine would allows its entry and sequester hydrogen ions by protonation this would accumuates in the acidic environment of endosomes (b) Thereby, the pH of the environment increases and it further inhibits or reduces the activity of lysozyme ezymes (c) The increment in the pH, further causes deactivation of P-Glycoprotein in the membrane and efflux drugs.