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If a protein contains a signal sequence for the ER and a nuclear localization sequence, where...

If a protein contains a signal sequence for the ER and a nuclear localization sequence, where do you think the protein will localize?

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Answer #1

Answer: If a protein contains a signal sequence for the ER and a nuclear localization sequence, then the protein will get localized to the ER, not to the nucleus.

Explanation:

  • Protein which contains signal sequence is recognized by Signal Recognition Particle and are transported to the surface of rough-ER, where they are synthesized on membrane-bound ribosomes (rough-endoplasmic reticulum).
  • These proteins are usually transported to the plasma membrane, lysosomes, secretory vesicles.
  • Protein which contains does not signal sequence is synthesized on free ribosomes in the cytosol.
  • These proteins are usually transported to the nucleus, mitochondria, chloroplast.
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