Question

the PFA-100 closure time is affected by!

circle all that apply. give rationale.

vWF activity

RBC count/hematocrit

aspirin

platelet count

platelet activity

Answer 1

Correct answers are :

vWF activity :

RBC count/hematocrit

aspirin

platelet count

platelet activity

Reason: PFA-closure time is affected by all of the above.PFA closure time depends on von Willebrand factor (VWF) that binds to the platelet membrane glycoprotein (GP) receptors i,e Ib/IX/V and integrin α IIbβ 3 (IIb/IIIa).Apart from that PFA closure time also depends on the functioning of the plateles,on the number of platelet number and on the RBC count/ hematocrit to some extent.