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List the reaction of the citric acid cycle that requires the input of a lot of...

List the reaction of the citric acid cycle that requires the input of a lot of energy (approx. 7kCal). List all the products produced. Is there an oxidation of a carbon atom involved? What makes it different from other reactions that produce energy?

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Answer #1

reaction with lot of energy input:

isocitrate ------------- -ketoglutarate + CO2+ NADH2 ( oxidation decarboxylation )

-ketoglutarate -------- succinyl CoA +CO2+NADH ( oxidation decarboxylation )

succinyl CoA -------- succinate +ATP+CoA-SH (substrate level phosphorylation )

succinate ---------- fumarate +FADH2( dehydrogenation )

yes there an oxidation of a carbon atom involved , all the oxidative decarboxylation reaction in this cycle is due to carbon oxidation .

citric acid cycle reaction :

acetyl-CoA +3NAD+ + FAD + ADP+ 3H2O ---------- 2CO2 + 3NADH + FADH2 + ATP + H2O

one glucose molecule undergo glycolysis it yield two pyruvate and two Acetyl CoA .

two acetyl group enter the citric acid cycle and yield 4CO2 + 2ATP + 6NADH +2FADH2

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