Question

Approximately how identical (as a % to one decimal place, for example 50.5%) are any two homologous human chromosomes? In total, approximately how many nucleotide differences exist between any two complete human haploid nuclear genomes?

Answer 1

Homologous chromosomes are very similiar and will have around 99 percentage of identical nucleotides. Homologous chromosomes are obtained by getting 1 chromosome from mother and another chromosome from father. Eventhough they are homologous , chromosomes from 2 organisms might have slight nucleotide difference or allele difference when joined together that is where the 1 percent of identity it looses.

Human haploid genome has 3.2 *109 bp and it has 99 percentage of similarity hence there could be 320 *105 nucleotides or 1 percentage of nucleotides could be different