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The signal sequence for import of a protein into the mitochondria is a. hydrophobic beta-sheet b.KDEL...

The signal sequence for import of a protein into the mitochondria is

a. hydrophobic beta-sheet
b.KDEL
c.hydrophobic alpha-helix
d.amphipathic alpha helix

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Answer #1

D. The signal sequence for import of a protein into the mitochondria is amphipathic alpha helix.

The signal sequence for importing proteins to mitochondria is an amino acid chain in the N-terminal sequence of the polypeptide. The length is about 20-50 residues.

This sequence has a tendency to fold into an alpha helical structure having positive charged amino acids like Arg and Lys residues at one side and hydrophobic amino acids on the other side. The presence of both residues makes this an amphipathic helix. The signal sequence is recognized and transported to mitochondrial matrix where the sequence is cut off by a signal peptidase.

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