Question

Individuals heterozyogous for a balanced translocation experiment have decreased fertility and often experience miscarriages? Otherwise these individuals are phenotypically normal. What are the explanations for these multiple or pleiotrophic phenotypes?

These individuals have a ~30% chance of having a normal child.

These individuals have a higher risk for cancer.

When recombination occurs during meiosis, many of the gametes are carrying large deletions and duplication that are inviable.

During meiosis, some of the gametes have large regions missing and other regions duplicated

It is unlikely that these individuals will have a healthy child.

the translocation did not interrupt any genes

Answer 1

Balanced translocation is the detachment of a part of chromosome from the chromosome and reattachment of the chromosome on the same chromosome at a different position. When gametes are produced by this balanced translocations, the gametes will either have deletions or duplications in them and these will result mostly in the production of a healthy child. Hence the correct option is :

During meiosis, some of the gametes have large regions missing and other regions duplicated.

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