Question

can zero order drugs reach steady state? and how if it can?

Answer 1

For drugs that exhibit zero-order kinetics (saturable elimination), half-life generally increases with dosage because a constant amount (not proportion) of drug is eliminated.

With multiple or continuous dosing regimens, the amount of drug in the body continues to accumulate until the rate of drug entering the body equals the rate of elimination from the body. Once this equilibrium is achieved, the system is said to be at a steady-state, and the average concentration in the body does not change.