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Shown below is the structure of doxorubicin (Adriamycin) which is useful for many types of cancer...

Shown below is the structure of doxorubicin (Adriamycin) which is useful for many types of cancer . Which of the following is true about this agent? A. It intercalates into DNA, inhibits Topo II, and forms reactive oxygen species (ROS). B. It’s an anthracycline type of drug. C. It’s administered orally. D. A, B and C. E. A and B.

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Answer #1

Ans: The correct option is E (Both A and B are true)

  • Doxorubicin intercalates between DNA base pairs and for the complex. Doxorubicin stabilizes DNA–topoisomerase II complex by inhibiting  DNA–topoisomerase II activity. Inhibition results in the downregulation of DNA replication. Doxorubicin induces ROS generation in cancerous cells. So, this statement is correct.
  • Anthracyclines are referred to as the class of chemotherapeutic drugs. Doxorubicin is also a chemotherapeutic drug and belongs to anthracyclines type of drugs. So, this statement is correct.
  • Bioavailability of chemotherapeutic drugs is limited and hence, doxorubicin is administered via intravenous routes. So, this statement is incorrect.
  • Option D is not the right choice as all options (A, B & C) are not correct.
  • Option E is the right answer as only statement A and B are correct.
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