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Which of the following amino acids have the least and most favorable phi and psi angle...

Which of the following amino acids have the least and most favorable phi and psi angle on the Ramachandran plot?

Select one: a. Proline and Alanine b. Proline and Glycine c. Histidine and Glycine d. Tryptophan and Alanine

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Answer #1

Ans.b) Proline and Glycine

Proline has restrictions in phi-psi space that arise from the 5-membered ring. Phi is restricted to approxamatly -60 by the ring and psi angles fall into two groupings near -45 and +135 in the helical and sheet regions of the Ramachandran plot.

In glycine, the ψ angle is typically clustered at ψ = 180° and ψ = 0°.

They(proline and glycine) exist at the two extreme ends of the spectrum in terms of phi/psi rotation. Gly is the least restricted, Pro is the most restricted. Thus Gly can appear anywhere & Pro only in certain places.

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