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using the drosophila model of SCA1 what was the protein kinase they found to be implicated...


using the drosophila model of SCA1 what was the protein kinase they found to be implicated in SCA1 associated neurodegeneration and why is this knowledge useful with respect to treating the disease

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The protein kinase implicated in SCA1 associated neurodegeneration in drosophila model of SCA1 is "NLK (Nemo like kinase)" which is a serine/threonine kinase.

This knowledge about this protein is useful in treating disease because this protein is a key molecule modulating disease toxicity in spinocerebellar ataxia type 1 (SCA1) and it has been found in the study that reduced level of NLK suppress the behavioral and neuropathological phenotypes in SCA1 knock-in mice.

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