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What is the impact of high ATP levels on the enzymes that are involved in glycolysis?

What is the impact of high ATP levels on the enzymes that are involved in glycolysis?

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Answer #1

High levels of ATP allosterically inhibit the enzyme phosphofructokinase in the liver, as a result of which it lowers its affinity for fructose-6 -phosphate. ATP binds to a specific regulatory site other than the catalytic site, which converts the hyperbolic binding curve of fructose-6-phosphate into a sigmoidal one.

ATP inhibits the activity of the enzymes involved in glycolysis. If there is already plenty of ATP in the cell, it does not need to make more through the process of glycolysis.

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