Question

10) An engineer is designing a high-tech new nano-robot that can be injected into the bloodstream to locate and destroy blood clots. The robot will swim through the bloodstream using a molecular motor made of bacterial flagellin. When it reaches the clot, the robot will then release a net of DNA bound to the human enzyme plasmin, which can adhere to the clot and dissolve it. What mistake has the engineer made in her design?

options

	It is not possible to use DNA as a net
	No mistakes are evident in the limited information provided
	The plasmin released by the robot will cause an innate immune response by the host
	The flagellin in the molecular motor will cause an innate immune response by the host

Answer 1

Answer D.  The flagellin in the molecular motor will cause an innate immune response by the host

Because flagellin is a bacterial protein found in flagella which is an virulent factor and now immerge as one of the potent immune activator in host.

Option a is not correct because local structural transitions from the common double helical B-DNA into other DNA forms can be functionally possible by the advancement of science. Other DNA structure are cruciform structure, Z-DNA structure, Triplex DNA structure, are possible to make thanks to the supercoiling of DNA molecule. So net DNA also can’t be said impossible to make.

Option C is also not seems right because plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots. So innate immune system of host will not activated.