1-The transport receptor, exportin, functions to transport:
a)RNA to the nucleus when associated with GDP-bound Ran protein.
b)RNA to the cytoplasm when associated with GTP-bound Ran protein.
c)RNA to the cytoplasm when associated with GDP-bound Ran protein.
d)RNA to the nucleus when associated with GDP-bound RNA protein.
2-Which of the following is not true regarding mRNA splicing and mRNA export from the nucleus?
a)Spliced mRNA are exported with the assistance of the Ran pathway.
b)All of the given answers are true.
c)Exon junction complexes assist in mRNA export.
d)An mRNA that undergo splicing is exported more rapidly than an indentical mRNA which has the intron genetically removed.
3-How is directionality maintained for proteins that need to go in and out of the nucleus?
a)The localization of import and export receptor proteins.
b)The localization of specific nuclear proteins.
c)The localization of Ran-GTP and Ran-GDP.
1-The transport receptor, exportin, functions to transport:
b)RNA to the cytoplasm when associated with GTP-bound Ran protein.
2-Which of the following is not true regarding mRNA splicing and mRNA export from the nucleus?
a)Spliced mRNA are exported with the assistance of the Ran pathway.
Why: Spliced mRNA are transported via Ran independent pathway.
3-How is directionality maintained for proteins that need to go in and out of the nucleus?
Most likelihood answer is The localization of Ran-GTP and Ran-GDP.
c)The localization of Ran-GTP and Ran-GDP.
Why: It is the energy driven process which is catalyzed by Ran GTPase. Hence, it regulates the directional transport by GTP hydrolysis.
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