Question

All of the following are true of Wnt EXCEPT: a) It determines "stem cellness". b) It...

All of the following are true of Wnt EXCEPT:

a) It determines "stem cellness".

b) It is an extracellular protein.

c) Inappropriate activation of the Wnt signal causes colon cancer only when it occurs in the villi of the colon.

d) The Wnt signal causes the cell to continue the cell cycle.

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Answer #1

The answer is --- c) Inappropriate activation of the Wnt signal causes colon cancer only when it occurs in the villi of the colon.

Reason ---

The colon contains crypts having flat surface epithelium rather than villi. Villi are present in small intestine. Mucus secreting goblet cells are abundantly found in colon. The Wnt signalling is very important factor in the spatial organisation of epithelium in the colon.

Any mutations in the Wnt pathway may cause Intestinal cancer .

Therefore , the option of - Inappropriate activation of Wnt signal causes colon cancer only when it occurs in the villi of colon is incorrect one.

While the other options are true. Wnt is an extracellular protein which is responsible for the cell cycle and it determines the stem cellness. Defects in this protein is responsible for developmental defects. Therefore, all other options are correct.

Thank you.

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