Question

Covid 19 is caused by a novel corona virus strain, not seen in the human population until now. Describe the clonal selection theory. How might clonal selection be impacting the spread of this disease and human resistance to infection?

Answer 1

Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is selected from the preexisting cell pool of differing antigen specificities and then reproduced to generate a clonal cell population that eliminate the antigen.

In case of COVID19 the extraction of genomic DNA from the Tcells should be done in which T cell receptor sequence appears to be expanded in people who are exposed to or have active covid infection. Then immunosequencing, computational biology as well as invitro studies to map the most likely T cell receptor sequences that will bind to and potetially neutralise the virus.