Question

(a)Explain why congenital and experiment aneuploidy during mitosis is known to generate abnormal phenotypes in cancer.

(b) In mosaic with XX and XO cell lines, the phenotype may vary from complete Turner’s syndrome to a completely normal-looking woman. Similarly, in XO/XY mosaics, the phenotypic variation ranges from complete Turner’s syndrome to a normal-looking (but infertile) man. Explain these phenotypic variations.

Answer 1