fatty acids are broken down to acetyl-coA by means of beta oxidation inside the mitrochondria ,whereas fatty acids are synthesized from actyle-coA outside the mitrochondria ,in the cytosol . The two pathways are distinct, not only in where they occur, but also in the reactions that occur, and the substrates that are used
Degradation of fatty acids with even-numbered double bonds results in 2,4-dienoyl-CoA esters, which are oxidized as shown on the left. 2,5-dienoyl-CoA esters arising from odd-numbered double bonds can be oxidized either via an isomerase-dependent pathway (middle) or via a reductase-dependent pathway.
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