Which genes are found on either side of TAS2R38? How do their
gene structures (e.g. introns and exons) differ from that of
TAS2R38? What do several of the more distant genes have in common
structurally with TAS2R38? Propose an explanation for the origin of
these similar genes.
TAS2R38 ,this genes encodes a seven transmembrane G protein coupled receptors that controls the abiltiy to taste glucosinolates, a bitter tasting compounds found in plants of brassica sp.Synthetic Compounds phenylthiocarbamide (PTC) and 6-propylthiouracil (PROP)have been identified asligands for this receptors and have been used to test the genetic diversity of this gene.
TAS2R are positioned on chromosome 7 are rather polymorphic.Among the recognized genetic variants the diplotype of TAS2R38 consisting 3 single nucleotide polymorphism(SNP) A49P,V262A and I296V has been well described for its purposeful modification.
Other name of gene: PTC, THIOT,T2R61,T2R28
Proteins are excepted to have molecular function and to localize in various compartments.
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