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Where do NADH and FADH2 get the electrons that they bring to the electron transport chain?

Where do NADH and FADH2 get the electrons that they bring to the electron transport chain?

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Answer #1

NADH and FADH2 gets electrons in various steps of cellular respiration, these are :-
1. Glycolysis - In this step total 2 NAD+ gets electrons and get converted into 2 NADH per glucose.
Step is - Conversion of glyceraldehyde-3 phosphate to 1,3- bisphosphoglycerate.

2. Pyruvate decarboxylation - In this step one NAD+ per pyruvate gets electrons and converted to NADH.
• Pyruvate dehydrogenase complex helps in this step.

3. Krebs cycle - In this cycle, total 3 NAD+ and 1 FADH get electrons and get converted to NADH and FADH2.
Steps are -
(a) for NADH -
• Conversion of isocitrate to alpha ketogluterate and then in succinyl coA.
• Conversion of malate to oxaloacetate.
(b) for FADH2 -
• Conversion of succinate to fumarate.

Now NADH and FADH2 transfer these electrons to electron transport chain and make large amount of ATP.

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