Question

Explain the term organoid. what are the characteristics of intestinal organoids that make them ideal for personalized medicine

Answer 1

An organoid is a miniaturized and simplified version of an organ produced in vitro in three dimensions that shows realistic micro-anatomy. It enable to study how cells interact together in an organ, their interaction with their environment, how diseases affect them and the effect of drugs. In vitro culture makes this system easy to manipulate and facilitates their monitoring.

Intestinal organoids are self-renewing three-dimensional structures comprised of intestinal stem cells and their differentiated epithelial progeny allow for more facile and robust exploration of cellular activity, cell organization and structure, genetic manipulation, and vastly more physiologic modeling of intestinal cells which help them to be ideal for personalized medicine.