Question

B cells traffic between the light and dark zones in the germinal center to acquire high affinity antibodies.

What occurs in the dark zone?

a. Somatic hypermutation.

b. Affinity maturation.

c. Interaction with Tfh cells.

d. Both a and b

e. Both b and c.

Answer 1

ANSWER -CORRECT OPTION IS A

here somatic hypermutation is the two processes which occurs in the dark zone in the geminal centers

Somatic hypermutation means an immune response of the immune system of the body where the immune system adapts itself to the new foreign particle in the body

while, the affinity maturation and interaction with tfh cells occurs in the light zone , the affinity maturation occurs after the interaction with the tfh cells in the light zone., affinity maturation is a process in which the tfh induced cells produce antibodies with increased affinity for the antigens, and this occurs in the light zone of the germinal centers.

hence the correct answer is a