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For a neutral lipophilic drug would you use sonophoresis?

For a neutral lipophilic drug would you use sonophoresis?
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Sonophoresis is a drug delivery method where ultrasound is used to increase the absorption of topical compounds into the epidermis, dermis and skin appendages. The medication usually consists of hydrophilic molecules and macromolecules.

Pharmacists compound the drugs by mixing them with a coupling agent (gel, cream, ointment) that transfers ultrasonic energy from the ultrasound transducer to the skin.

Now if the drug is lipophilic then it is easy to administer in this manner.

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