Question

The acetyl-coA carboxylase is activated by:

	A.	polymerization
	B.	Palmitoyl-coA.
	C.	glucagon and epinephrine
	D.	depolymerization

Answer 1

Answer is A. polymerization.

Explanation

Citrate is an allosteric activator of acetyl-CoA carboxylase. It stimulates polymerization of an inactive form of the enzyme into an active form. Thus polymerisation leads to activation of acetyl-CoA carboxylase.

Why other options is incorrect:

Glucagon and epinephrine inactivates the acetyl-coA carboxylase.

Palmitoyl CoA and AMP also inhibit the carboxylase, rather than activating it.

Since polymerization cause activation, there is no way that depolymerization can cause activation.

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