Question

Metabolite receptors bind to ___________________.

	A.	second messengers
	B.	DNA
	C.	GPCRs
	D.	Protein Kinase A
	E.	All of the above is true.

Answer 1

ANSWER :- c.) GPCRs ( G protein- coupled receptors).

Several G protien-coupled receptors (GPCRs) are activated by intermediates of energy metabolism-such as fatty acids, saccharides, lactate and ketone bodies. These receptors are able to sense metabolic activity or levels of energy substrate and use this information to control the secretion of metabolic hormone or to regulate the metabolic activity of a particular cell. Moreover, most of theae receptors appears to be involved in the pathophysiology not metabolic disease such as diabetes, ovesity, etc.

Metabolite receptors are extensively expressed in enteroendocrine and pancreatic endocrine, in metabolic organs, and in immune cells. These metabolic receptors can signal through several different signal transduction pathways.