Question

The amino acid sequence Thr-Phe-Ala-Glu-His-Tyr is mutated to Thr-Phe-Val-Glu-His-Tyr. This is consistent with which class of mutations?

nonsense

frameshift

missense

Answer 1

In case of nonsense mutation, a codon coding for amino acids is mutated to stop codon.

A frameshift mutation is caused due to deletion or insertion of one base in the sequence. Due to insertion or deletion, the whole reading frame is changed and the mutated gene has amino acids sequence that was not present in the normal peptide.

In missense mutation, one amino acid is mutated to another amino acid.

In the mutated sequence, only one amino acid is mutated. Alanine is mutated to valine. So mutation is missense class of mutation.

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