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QUESTION 48 WHich of these lipid is not typically used for attaching proteins to the cytoplasmic...

QUESTION 48 WHich of these lipid is not typically used for attaching proteins to the cytoplasmic face of cell membrnaes?

Myristate

Farnesyl

GPI

Geranyl

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Answer #1

Correct option- GPI

This is the correct option because Glycosylphosphatidylinositol (GPI) lipid anchors proteins to the exoplasmic leaflet of the cell membrane but it does not anchor the protein to the cytosolic leaflet of cell membrane. Thus, GPI lipid is not typically used for attaching proteins to the cytoplasmic face of cell membranes

Reason for incorrect option-

Myristate anchors the proteins to the N- terminal glycine residue whereas Farnesyl and Geranyl lipids anchor the protein by thioether bond to C-terminal cysteine in the cytosolic leaflet of the cell membrane.

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