Question

How can a germline mutation predispose someone to particular types of cancer? How is this similar/different to development of cancer in someone without any such germline mutation?

Answer 1

germline mutation are similar somatic mutation. they are caused by the exposure to harmful substances like uv. the DNA of the germ cells are damaged due to this exposure. this type of mutation involving in 5 -10 % of the cancers. the germ cells affected will be heritable. when TP53 is predisposed to cancers. is is happening due to the proteins produced by this gene suppress tumors. this type of cancers are called inherited cancer.

this cancer id different because, the cells affected by the germline mutation are sperm or egg at initial state. they are further copied into other cells and thereby the cancer is inherited. mutation is affecting reproductive cells. all other types of cancers are affecting after the birth . other cancers are not found in all cells of the body .