Question

Describe how Barrett’s esophagus is formed.

The formation of Barrett’s esophagus poses an increased risk for which type of cancer?

How are gastric contents prevented on reaching the esophagus?

Answer 1

Barrett's Esophagus.

• It is defined as type of premalignant condition in which the normal squamous lining of lower esophagus replaced by columnar epithelium.
• This columnar epithelium show intestinal metaplasia with goblet cells.

1. Cause.

It is an Adaptive response of esophagus to recurrent gastroesophageal reflux.

2. Incidence of malignancy.

• It is 40 times more prone to carcinoma.
• This metaplasia change to dysplasia and end form Adenocarcinoma.

3. Treatment for prevention gastric content reaching esophagus.

• High dose of Proton pump inhibitor like Pantaprazole ,Lansoprazole etc.
• Use of antacid .
• Use of H2 blockers like rantidine.
• Prevent reflux by Prokinetic drugs like Metaclopromide , Cisapride etc.

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