Question

1. list the enzymes/chemicals involved bone resorption and describe their functions

2. explain the effects of estrogen and anabolic steroids on bone growth

Answer 1

1. ANSWER: Cathepsin K, is the main enzyme produced by the osteoclast cells of the bone which is involved in the resorption of the bone. Cathepsin is proteinase enzyme. It results in bone degradation, primarily of type 1 collagen. It is also seen produced by the cancer cells that metastasize to the bone. Cathepsin k inhibitors are used as the treatment of osteoporosis.

2. ANSWER: Oestrogen is required for proper closure of epiphyseal plate of the long bones in both males and females. Oestrogen deficiency in young may lead to increased production of osteoclast and thus enchance bone resoprtion. Anabolic steroids are used as a treatment for osteoporosis as it increases the bone density by stimulating bone formation.