Neuron D and neuron E interact with neuron F. Neuron D will produce an EPSP of 3mV in neuron F; neuron E will produce an IPSP of -2mV in neuron F. The resting membrane potential in neuron F is -70mV and the threshold potential is -50mV.
Neuron D fires rapidly 3 times; simultaneously neuron E fires 6 times.
The resulting membrane potential in neuron F is
So the membrane will be hyperpolarized due to net negative signal by neurons D and E on F.
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