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35. Carbamazepine toxicity is associated with which of the following allele variant? A. HLA-B*57:01 B. HLA-C*14:29...

35. Carbamazepine toxicity is associated with which of the following allele variant?

A. HLA-B*57:01

B. HLA-C*14:29

C.HLA-B*15:02

D.CYP2C19*3

Science   Anatomy-And-Physiology   
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Answer #1

HLA-B*15:02

  • Carbamazepine is a drug used for the treatment of eiplepsy.
  • Human leukocyte antigen , HLA-B*15:02 is an allele which is associated with overdose of carbamazepine.
  • HLA is a protein , which play an important role in immune response.
  • Option A is wrong because HLA-B*57:01 is associated withdrug induced liver toxicity which include antiretroviral drugs.
  • Option B is wrong because HLA-C*14:29 is a MHC molecule .
  • Option D is wrong because CYP2C19*3 is associated with alzheimer's disease.
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